Chronic psychological stress damages mitochondria through increased oxidative stress and inflammation. Research shows that individuals under high stress show 40% less benefit from longevity interventions, including Urolithin A. Effective stress management techniques include: daily meditation (even 10 minutes helps), regular exercise, adequate sleep, social connection, and time in nature. Studies show that combining stress reduction practices with Urolithin A supplementation leads to dramatically better outcomes in cellular health markers. Your supplement works best when your stress hormones are under control.