Science-Backed Research
The Science Behind Urolithin A
From Nobel Prize-winning research on autophagy to groundbreaking clinical trials, backed by over 500 studies and 11 human clinical trials [4] involving 300+ participants.
10+
Years of research
Grounded in years of peer-reviewed research published by leading academic institutions worldwide
300+
Participants Studied
Across publicly available, peer-reviewed human studies on Urolithin A
500+
Studies on Urolithin A
Scientists have extensively explored the effectiveness of Urolithin A on health
99%
Satisfaction Rate
Based on expert testimonials and customer reviews
Backed by Medical Experts
Years of Development
What Makes
mitovia
Superior?
Engineered for maximum purity and potency, addressing cellular aging at its root cause — mitochondrial dysfunction.
99.9%
99.9% Ultra-Pure
Ensures maximum efficacy and safety
1000mg
1000mg Potent Serving
High-potency dose for optimal results
100%
Mitophagy Activation
Triggers cellular renewal process
12%
Performance Support
Clinically studied to support muscle endurance and function during aging [2]
Landmark Clinical Studies
Breakthrough Discovery
Nature Medicine • 2016
Preclinical
First study demonstrating Urolithin A’s ability to induce mitophagy and extend lifespan in model organisms
Phase I Clinical Trial
The mitophagy activator Urolithin A is safe and bioavailable in humans [3]
Nature Medicine • 2019
60 elderly adults
Confirmed safety and bioavailability of Urolithin A in humans, showing improvements in cellular and mitochondrial health biomarkers
Phase I Clinical Trial
Nature Medicine • 2019
66 adults (40-64)
Demonstrated improvements in muscle endurance and mitochondrial efficiency in middle-aged adults after 4 months of supplementation
What is Mitophagy?
Mitophagy is your body’s natural quality control system for mitochondria – the powerhouses of your cells. As we age, this process becomes less efficient.
Urolithin A is the first and only known compound that can reactivate mitophagy in humans, helping to clear out damaged mitochondria and promote the growth of new, healthy ones.
Research associates mitophagy with improved cellular energy, muscle function, and markers of vitality observed in aging models and human studies.
Research Timeline
2016
Discovery
First identification of Urolithin A’s mitophagy effects
2019
Safety
Human safety and bioavailability confirmed
2022
Efficacy
Clinical benefits demonstrated in trials
2025
Available
Premium formulation now accessible
See the differences
Urolithin A
Supplements
The Pioneer in Pure Urolithin A Supplementation
mitovia
Others
Ultra Purity
99.9%
nominal-85%
Third-Party Tested
Clinical-Strength Dose
1000mg
250-500mg
Matches Clinical Studies
Backed by Published Research
500+ Studies
Limited
All Natural
Non-GMO & Vegan
Varies
GMP Certified
Varies
mitovia
CoQ10
Creatine
Spermidine
NMN
Directly activates mitophagy
Partial
Targets a root cause of age-related cellular energy decline
Partial
Partial
Partial
Supports cellular renewal & autophagy
Partial
Shown to improve biological age markers
Partial
Partial
Limited
Benefits without exercise
Complete human clinical trials
Limited
Limited
High bioavailability
Featured in Leading Publications
Our science-backed approach to cellular health has been featured in top-tier scientific journals and health publications
Scientific Journal
Nature Medicine
“Urolithin A induces mitophagy and prolongs lifespan”
2016
Featured
Clinical Research
Science Translational Medicine
“Urolithin A improves muscle strength in aging adults”
2022
Featured
Safety Study
Nature Metabolism
“The mitophagy activator urolithin A is safe and bioavailable”
2019
Featured
Health Authority
Harvard Health
“The promise of cellular renewal for healthy aging”
2023
Industry Publication
Longevity Research
“Urolithin A: The postbiotic revolution in anti-aging”
2023
Technology
MIT Technology Review
“How supplements can activate your cellular cleanup crew”
2023
Mentions refer to independent scientific publications and media coverage of Urolithin A research. No endorsement by publishers is implied.
Quality & Safety Certifications
GMP Certified
Good Manufacturing Practice certified facilities
Third-Party Tested
Every batch tested for purity and potency
FDA Registered
Manufactured in FDA registered facility
Clinical Grade
Formulated to match clinical study doses
Ready to Experience the Science?
Get pharmaceutical-grade Urolithin A backed by clinical research
References
- Ryu D, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine. 2016;22(8):879-888.
- Liu S, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022;3(5):100633.
- Andreux PA, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism. 2019;1(6):595-603.
- Singh A, et al. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA Network Open. 2022;5(1):e2144279.
What Is Urolithin A and How Does It Work?
Urolithin A is a naturally occurring postbiotic compound and the first molecule clinically shown to activate mitophagy — the body's process of recycling damaged mitochondria into new, healthy ones. Produced by gut bacteria from ellagitannins in pomegranates and berries, only about 40% of people can convert enough naturally. Peer-reviewed research in JAMA Network Open and Nature Medicine confirms that supplementing 1000mg daily improves muscle strength by up to 12% and enhances mitochondrial health in adults over 40.